Mathematical models of the acute inflammatory response
نویسندگان
چکیده
منابع مشابه
Mathematical models of the acute inflammatory response.
PURPOSE OF REVIEW Trauma and infection elicit an acute inflammatory response. In certain circumstances the degree of the acute inflammatory response may result in pathologic manifestations, namely, sepsis and multiple organ failure. Despite an extensive series of clinical trials designed to modulate inflammation in sepsis, only one compound, activated protein C, has emerged from more than 250 f...
متن کاملA reduced mathematical model of the acute inflammatory response: II
Bacterial lipopolysaccharide (LPS; endotoxin) is a potent immunostimulant that can induce an acute inflammatory response comparable to a bacterial infection. Experimental observations demonstrate that this biological response can be either blunted (tolerance) or augmented (potentiation) with repeated administration of endotoxin. Both phenomena are of clinical relevance. We show that a four-dime...
متن کاملA Mathematical Model of Acute Inflammatory Response to Endotoxin Challenge
The body responds to endotoxins by triggering the acute inflammatory response system to eliminate the threat posed by gram-negative bacteria (endotoxin) and restore health. However, an uncontrolled inflammatory response can lead to tissue damage, organ failure, and ultimately death; this is clinically known as sepsis. Pro-inflammatory mediators (e.g., interleukin-6 (IL − 6) and tumor necrosis f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Critical Care
سال: 2004
ISSN: 1070-5295
DOI: 10.1097/01.ccx.0000139360.30327.69